NEWS & KNOWLEDGE

Microfluidic Sperm Sorting (MSS) is an innovative method for selecting high-quality sperm using a specially designed device equipped with microfluidic channels. These channels mimic the body’s natural sperm-selection process inside the female reproductive tract. Only healthy, highly motile sperm with intact DNA can navigate through the intricate channels to the opposite side of the device, while weaker or DNA-damaged sperm are unable to pass through.

Unlike traditional sperm preparation methods, microfluidic cell sorting selects sperm based on their natural characteristics without the need for centrifugation, which is known to increase DNA fragmentation.

As a result, MSS provides sperm that are highly motile, fast-moving, free from debris and reactive oxygen species (ROS), and exhibit significantly lower levels of DNA fragmentation compared to other preparation techniques. These high-quality sperm are ideal for use in IUI, IVF, or ICSI, helping improve fertilization outcomes, embryo quality, and overall treatment success rates.

Image of Microfluidic Sperm Sorting (MSS)

Benefits of Microfluidic Sperm Sorting

1. Reduces the need for centrifugation compared to traditional methods, resulting in lower sperm DNA fragmentation.
2. Minimizes the generation of Reactive Oxygen Species (ROS), which can damage sperm.
3. Mimics natural selection, allowing only sperm that are motile, morphologically normal, and capable of fertilization to pass through.
4. Provides high-quality sperm suitable for fertilization, increasing the chances of success in IVF/ICSI.

Who Can Benefit from Microfluidic Sperm Sorting?

• Men with high sperm DNA fragmentation levels
• Men experiencing male-factor infertility (poor semen quality)
• Individuals who want to reduce ROS exposure or avoid centrifugation
• Couples who have undergone IVF/ICSI without success
• Couples looking to improve embryo quality and increase pregnancy rates

Article by

Ms. Piyarat Sophaboon, M.Sc., Embryologist

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