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PGT-A vs PGT-M: What’s the Difference?


What is PGT-A?

PGT-A (Preimplantation Genetic Testing for Aneuploidies) is a genetic screening test used to evaluate chromosomal abnormalities in embryos. After the ICSI procedure and once the embryo reaches the blastocyst stage, a small biopsy of 5–10 cells are taken and analyzed before embryo transfer into the uterus.

Benefits of PGT-A:

  • Selects embryos with normal chromosomal composition
  • Reduces the risk of miscarriage
  • Decrease the number of IVF/ICSI cycles needed
  • Screens for chromosomal abnormalities such as Down syndrome

Who should consider PGT-A?

  • Women aged 35 and above
  • Patients with a history of recurrent miscarriage (2 or more times)
  • Couples with multiple unsuccessful IVF/ICSI attempts

What is PGT-M?

PGT-M (Preimplantation Genetic Testing for Monogenic Disorders) is a diagnostic test used to detect specific genetic diseases caused by mutations in a single gene (single-gene disorders) within embryos.

Before undergoing PGT-M, embryos are typically screened with PGT-A to ensure normal chromosomal status. Only then will they proceed to PGT-M testing.

Benefits of PGT-M:

  • Reduces the risk of passing on inherited genetic diseases
  • Prevents single-gene disorders before pregnancy begins

Who should consider PGT-M?

  • Couples with a family history of genetic disorders
  • Couples who are known carriers of genetic conditions
  • Couples who have previously had a child with a genetic disease

Should You Choose PGT-A or PGT-M?

The choice between PGT-A and PGT-M depends on several factors, including:

  • Age
  • Medical and fertility history
  • Previous treatment outcomes
  • Family history of genetic conditions

Ultimately, the decision should be guided by a fertility specialist who can tailor the treatment plan to your specific needs.

Our Approach at N.I.C IVF Clinic

At N.I.C IVF Clinic, choosing between PGT-A and PGT-M is not just about advanced technology, it’s about precise and personalized embryo screening to give your future child the best possible start in life.

Every step is carefully managed by our experienced medical team, with comprehensive evaluation of both medical and genetic histories. Because selecting the right embryo is a crucial step toward a healthy and successful pregnancy.

 

For further information, please contact:
LINE Official Account: @nic_clinic or https://lin.ee/Mmq6m2K
Tel: +66 2-007-3973 or +66 95-370-2483

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