NEWS & KNOWLEDGE
Irregular Menstrual Cycles: What Should Be Done Before ICSI?
Irregular menstrual cycles are one of the significant causes of infertility and should be thoroughly evaluated before undergoing Intracytoplasmic Sperm Injection (ICSI). Proper preparation, particularly comprehensive medical evaluation and hormonal assessment by a fertility specialist, can significantly improve the chances of achieving a successful pregnancy.

What Is an Irregular Menstrual Cycle?
An irregular menstrual cycle refers to abnormalities in the menstrual pattern, such as:
- Menstrual cycles that are unusually short or long
- Missed periods or absence of menstruation for several consecutive months
- Abnormal bleeding between menstrual cycles
These conditions are often associated with hormonal imbalances and ovulatory dysfunction, which directly affect fertility planning and the success of ICSI treatment.
Irregular menstruation may also indicate underlying conditions, including:
- Anovulation or irregular ovulation
- Polycystic Ovary Syndrome (PCOS)
- Sex hormone imbalance
- Thyroid disorders
These conditions can negatively affect oocyte quality and ovarian response to stimulation. If not properly evaluated and managed prior to ICSI treatment, pregnancy success rates may be reduced.
What Should Be Done Before ICSI If You Have Irregular Menstrual Cycles?
1. Comprehensive Evaluation by a Fertility Specialist
The physician will assess overall health, menstrual history, and perform pelvic ultrasound examinations to evaluate ovarian function and identify potential risk factors related to infertility. This information is essential for developing an individualized and effective treatment plan.
2. Hormonal Evaluation
Hormonal testing plays a crucial role in assessing ovarian function and the endocrine system related to fertility, including:
- FSH, LH, and Estradiol to evaluate reproductive system function
- AMH (Anti-Müllerian Hormone) to assess ovarian reserve
- Progesterone to confirm ovulation
- Thyroid function tests to evaluate thyroid health
- Prolactin levels, as elevated prolactin may interfere with fertility

Why Is Hormonal Testing Important Before ICSI?
Hormonal evaluation prior to ICSI enables physicians to:
- Accurately analyze and assess each patient’s reproductive condition
- Select the most appropriate treatment strategy on an individual basis
- Optimize the type and dosage of ovarian stimulation medications
- Reduce the risk of complications during fertility treatment
If you have irregular menstrual cycles and are planning to undergo ICSI treatment, it is important to consult a fertility specialist for a thorough health and hormone evaluation. These assessments help doctors understand your reproductive health, identify possible causes of infertility, and plan the most appropriate treatment for you. Proper preparation before ICSI can improve treatment outcomes and increase the chance of achieving a healthy and successful pregnancy.
Article by
Assoc. Prof. Dr. Mathchuporn Suksaprasert, MD
(Medical License No. 27172)
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