NEWS & KNOWLEDGE

Supporting embryo development and implantation with SAGE 1-Step™ GM-CSF culture and transfer medium

What is SAGE 1-Step™ GM-CSF?

SAGE 1-Step™ GM-CSF is an embryo culture medium specifically designed for use after embryo warming. It is developed based on the widely used SAGE 1-Step™ medium, which has long been established in embryo culture systems.

SAGE 1-Step™ GM-CSF represents a new standard in embryo culture and embryo transfer media. It is enriched with key components, including Hyaluronan and GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor). These components help create an optimal environment for embryo development, reduce cellular stress, decrease embryo apoptosis, and increase the likelihood of successful implantation.

Why Choose SAGE 1-Step™ GM-CSF?

• Single-Step Medium

Allows continuous embryo culture until the day of transfer without the need to change media, helping to minimize embryo stress.

• GM-CSF Supplementation

GM-CSF is an important protein that supports communication between the embryo and the endometrium, enhances implantation potential, and reduces embryo cell death (apoptosis).

• Suitable for Both Culture and Transfer

Can be used throughout embryo culture and during embryo transfer procedures (Culture & Transfer).

Clinical Benefits of GM-CSF

• Enhances communication between the embryo and the endometrium
• Supports efficient embryo development
• Protects embryos from cellular stress and reduces apoptosis
• Increases implantation potential
• Supports appropriate immune modulation for implantation
• Promotes ongoing pregnancy
• Improves overall pregnancy success rates

An Advanced Treatment Option

SAGE 1-Step™ GM-CSF is an advanced option for both embryo culture and embryo transfer, supporting optimal conditions throughout the treatment process.

Scientific Evidence Supporting GM-CSF

• Embryos cultured in SAGE 1-Step™ GM-CSF demonstrate improved morphological quality, including reduced fragmentation and blastomere inequality
• Higher implantation rates and improved ongoing pregnancy rates compared with conventional embryo culture media

Who May Benefit from GM-CSF?

• Women with a history of unsuccessful IVF/ICSI treatments
• Patients with recurrent miscarriage
• Patients with previous failed embryo transfer cycles
• Advanced maternal age patients
• Patients undergoing frozen embryo transfer with poor-quality embryos